A widely used program called Rosetta, which was originally developed as a structure prediction tool at the University of Washington, was adapted to solve a wide range of common computational macromolecular problems. The program enabled scientific advances in computational biology, including protein design, enzyme design, ligand docking, and structure predictions for biological macromolecules and macromolecular complexes. With support from the National Science Foundation (NSF), Rosetta recently morphed into ROSIE: the Rosetta Online Server that Includes Everyone. It is now an easy-to-use science gateway (or web interface) that provides access to the Rosetta software suite. Learn more about ROSIE here.