The EMBL-Hamburg automated crystal structure determination platform is a system which contains several distinct decision-makers which executes a number of macromolecular crystallographic software programs to produce a software pipeline for automated and efficient crystal structure determination. A large number of possible structure solution paths are encoded in the system and the optimal path is selected by the decision-makers as the structure solution evolves. The processes have been optimised for speed so that the pipeline can be used effectively for validating the X-ray experiment at a synchrotron beamline. The platform offers SAD, S-SAD, SIRAS, 2W-MAD, 3W-MAD or 4W-MAD phase determination, molecular replacement (MR), MRSAD and MRSIRAS phasing. It also includes RIP and MRRIP phasing and the phasing protocols have been optimised for UV induced radiation damage X-ray data.

R. Caliandro, D. Dibenedetto, G. L. Cascarano, A. Mazzone and G. Nico Automatic [alpha]-helix identification in Patterson maps Acta Cryst. D68, 1-12

panjikar@embl-hamburg.de, Victor@embl-hamburg.de, msweiss@embl-hamburg.de

https://www.embl-hamburg.de/Auto-Rickshaw/

cyoun

Researchers should cite this work as follows:

• (2024), "Auto-Rickshaw," https://sciencegateways.org/resources/auto-rickshaw.

  BibTex | EndNote

1. Auto-Rickshaw
2. crystal structure determination
3. macromolecular crystallographic software