PowerFit automatically fits high-resolution atomic structures into cryo-EM densities. To this end it performs a full-exhaustive 6-dimensional cross-correlation search between the atomic structure and the density. It takes as input an atomic structure in PDB- or mmCIF-format and a cryo-EM density with its resolution; and outputs positions and rotations of the atomic structure corresponding to high correlation values. PowerFit uses the local cross-correlation function as its base score. The score is by default enhanced with an optional Laplace pre-filter and a core-weighted version to minimize overlapping densities from neighboring subunits.

Apache License Version 2.0

G.C.P. van Zundert, M. Trellet, J. Schaarschmidt, Z. Kurkcuoglu, M. David, M. Verlato, A. Rosato and A.M.J.J. Bonvin. The DisVis and PowerFit web servers: Explorative and Integrative Modeling of Biomolecular Complexes. J. Mol. Biol., Advanced Online Publication (2016).

a.m.j.j.bonvin@uu.nl

http://milou.science.uu.nl/cgi/services/POWERFIT/powerfit/

YouTube: https://www.youtube.com/watch?v=uxpG339UFJM&feature=youtu.be

Apache License Version 2.0

Github: https://github.com/haddocking/powerfit

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Researchers should cite this work as follows:

• (2024), "PowerFit," https://sciencegateways.org/resources/powerfit.

  BibTex | EndNote

1. atomic structures
2. cryo-EM
3. PowerFit